English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci ( HLA-DRB1 ,  PTPN22 ,  STAT4 ,  OLIG3/TNFAIP3  and  TRAF1/C5 ) for association with susceptibility and severity in an inception cohort.    Methods  The magnitude of association for each genotype was assessed in 1,046 RA subjects from the Yorkshire Early RA cohort and in 5,968 healthy UK controls. Additional exploratory subanalyses were undertaken in subgroups defined by autoantibody status (rheumatoid factor and anti-cyclic citrullinated peptide) or disease severity (baseline articular erosions, Health Assessment Questionnaire (HAQ) score and swollen joint count (SJC)).    Results  In the total RA inception cohort, the  HLA-DRB1  shared epitope (per-allele odds ratio (OR) = 2.1, trend  P  &lt; 0.0001),  PTPN22  (per-allele OR = 1.5, trend  P  &lt; 0.0001),  OLIG3/TNFAIP3  locus (per-allele OR = 1.2, trend  P  = 0.009) and  TRAF1/C5  locus (per-allele OR = 1.1, trend  P  = 0.04) were associated with RA. The magnitude of association for these loci was increased in those patients who were autoantibody-positive.  PTPN22  was associated with autoantibody-negative RA (per-allele OR = 1.3, trend  P  = 0.04). There was no evidence of association between these five genetic loci and baseline erosions or SJC in the total RA cohort, after adjustment for symptom duration.  TRAF1/C5  was significantly associated with baseline HAQ, however, following adjustment for symptom duration ( P  trend = 0.03).    Conclusions  These findings support the mounting evidence that different genetic loci are associated with autoantibody-positive and autoantibody-negative RA, possibly suggesting that many of the genes identified to date are associated with autoantibody production. Additional studies with a specific focus on autoantibody-negative RA will be needed to identify the genes predisposing to this RA subgroup. The  TRAF1/C5  locus in particular warrants further investigation in RA as a potential disease severity locus.

Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort