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The aim of the study was to evaluate the kinetic parameters of a specific serotonin transporter (SERT) and serotonin uptake in a mentally healthy subset of patients with fibromyalgia. Platelets were obtained from 40 patients and 38 healthy controls. SERT expression and functionality were evaluated through the measurement of [ 3 H]paroxetine binding and the [ 3 H]serotonin uptake itself. The values of maximal membrane binding capacity ( B  max ) were statistically lower in the patients than in the healthy volunteers, whereas the dissociation constant ( K  d ) did not show any statistically significant variations. Moreover, a decrease in the maximal uptake rate of SERT ( V  max ) was demonstrated in the platelets of patients, whereas the Michaelis constant ( K  m ) did not show any statistically significant variations. Symptom severity score (tiredness, tender points index and Fibromyalgia Impact Questionnaire) were negatively correlated with  B  max  and with  V  max , and positively correlated with  K  m . A change in SERT seems to occur in fibromyalgic patients, and it seems to be related to the severity of fibromyalgic symptoms.

Alteration of serotonin transporter density and activity in fibromyalgia.