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The belief that there exists an undifferentiated cell which can be programmed into another type of cell forms the basis of stem cell biology as we know it today. This has opened up possibilities of new treatment approaches for a whole host of diseases. In the field of vascular biology there is also thought to be a renewable source of cells present in the adult that have the potential to develop along either the haematopoietic or the endothelial lineages. Fascinatingly, recent studies have uncovered evidence suggesting that in rheumatoid arthritis (RA) such endothelial progenitor cells (EPC) are not only involved in synovial vascularisation, but may also underlie the increased cardiovascular morbidity and mortality known to be a feature of RA, thus linking two features of the disease that are well characterised but are as yet poorly understood.

It's all in the blood: circulating endothelial progenitor cells link synovial vascularity with cardiovascular mortality in rheumatoid arthritis?