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Background  The present study sought to investigate erythrocyte glutathione S-transferases (GST), NADH-Methaemoglobin reductase (NADH-MR) and Na + /K + -ATPase activities of hypoglycemic rats treated with ethanol/water (1:2  v/v ) extract of  A. sativa  as agent of glycemic control.    Methods  Hyperglycemia was induced by a single intra-peritoneal injection of 0.1 mol/L alloxan monohydrate in phosphate buffer saline (PBS) solution (pH = 7.4); dosage = 140 mg/kg. At the end of the experimental time ( t  = 76 h), erythrocyte GST, NADH-MR and Na + /K + -ATPase activities as well as serum fasting blood sugar (FBS) levels were measured by spectrophotometric methods.    Results  Serum FBS levels of control/normal (C/N) rats ranged between 72.93 ± 0.82–95.12 ± 0.92 mg/dL, whereas experimental rats without glycemic control gave: 249.41 ± 1.03–256.11 ± 1.23 mg/dL. Hyperglycemic rats treated with ethanol/water (1:2  v/v ) extract of  A. sativa  exhibited comparative reduced serum levels of FBS alongside with erythrocyte GST, NADH-MR and Na + /K + -ATPase activities. The average relative activities of the three enzymes and corresponding order of enzyme activity in hyperglycemic rats treated with ethanol/water (1:2  v/v ) extract of  A. sativa  was: NADH-MR = 60.99% > GST = 47.81% > Na + /K + -ATPase = 46.81%. In the same order, relative activities of the three enzymes in rats without glycemic control were: NADH-MR = 49.65% > GST = 23.69% > Na + /K + -ATPase = 17.02%.    Conclusion  Erythrocyte GST, NADH-MR and Na + /K + -ATPase activities gave insights into the pathophysiology of diabetic state and served as biomarkers for ascertaining therapeutic control in Type 1 diabetes mellitus.

Activities of three erythrocyte enzymes of hyperglycemic rats (Rattus norvegicus) treated with Allium sativa extract