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Lung transplantation remains the only viable treatment option for themajority of patients with advanced lung diseases. However, 5-yearpost-transplant survival rates remain low primarily secondary to chronicrejection. Novel insights from global gene expression profiles may providemolecular phenotypes and therapeutic targets to improve outcomes after lungtransplantation. We showed the presence of a significant number of dysregulatedgenes, particularly those genes involved in pathways and biological processessuch as immune response and defense, in the PBMCs derived from a cohort ofpatients after lung transplantation. The contribution of miRNAs in regulatingthese differential genes was also demonstrated.

MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation