English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Both steroid and sex hormones regulate multiple physiological functions including the stress response, fluid retention, metabolism and reproduction. They are synthesized from cholesterol via the precursor steroid pregnenolone. We previously reported early falls in HDL and LDL cholesterol levels in a fluid-resuscitated rat model of faecal peritonitis [1] and these could prognosticate as early as 6 h post-insult [2]. Pregnenolone may be converted to either (i) progesterone, corticosterone and then aldosterone via a common pathway or (ii) to dehydroepiandrosterone (DHEA), the precursor to testosterone and estradiol.

SEPSIS RESULTS IN EARLY CHOLESTEROL AND STEROIDOGENESIS PATHWAY ALTERATIONS