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Fibroblast growth factor 21 (FGF21) is a recently identified hormone that regulates metabolic homeostasis, with a potential role as a stress hormone [1]. Critical illness is hallmarked by insulin resistance and mitochondrial damage, metabolic alterations that increase circulating levels of FGF21 via the integrated stress response (ISR) [2]. Targeting normoglycemia during critical illness has shown to attenuate mitochondrial damage in the liver, the main source of FGF21 [3].

intensive care medicine experimental

FIBROBLAST GROWTH FACTOR 21 RESPONSE TO CRITICAL ILLNESS: EFFECT OF BLOOD GLUCOSE CONTROL AND RELATION WITH MITOCHONDRIAL DYSFUNCTION, THE INTEGRATED STRESS RESPONSE AND SURVIVAL