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MGC-0109 (ammonium tetrathiomolybdate) is a long-acting sulphide donor that reversibly inhibits mitochondrial respiration. We previously found that MGC-0109 reduced oxidative stress and doubled 6-hour survival in a severe haemorrhage/reperfusion rat model (1). Here we explore its utility in an organ-specific ischaemia/reperfusion injury.

EFFECTS OF MGC-0109, A SLOW-RELEASE SULPHIDE DONOR, ON MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY