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Actual guidelines for the management of severe sepsis and septic shock recommend to draw blood cultures before anti-infective therapy. The grade of recommendation for this approach is high, the evidence, however, is low (1C) [1]. Thus, data on the influence of anti-infective therapy on microbiology results in seriously ill patients are urgently warranted.

intensive care medicine experimental

INCIDENCE OF PATHOGEN DETECTION IN BLOOD CULTURES OF SEVERE SEPSIS AND SEPTIC SHOCK PATIENTS IS HIGHER, IF BLOOD CULTURES WERE DRAWN BEFORE ANTI-INFECTIVE THERAPY