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Rapid correction of hyponatremia can cause pontine myelinolysis and should be corrected by less than 10 mM/L within 24 hours. Hepatic cirrhosis is often associated with hyponatremia due to fluid retention and ascites. During liver transplantation, sodium may increase because of fluid administration and blood transfusions. Little is known regarding the frequency of rapid sodium increases during liver transplantation and whether such rapid corrections carry detrimental effects.

Incidence of rapid increase of plasma sodium during liver transplantation and ITS effect on outcome