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Magnesium is an N-methyl-D-aspartate receptor blocker and it's known to have analgesic effect([1, 2]). Hypomagnesaemia is often seen in major surgery and it is associated with higher morbidity, mortality, organ dysfunction, systemic inflammatory response syndrome and pulmonary hypertension([2, 4]). It's shown that intra-operative use of magnesium sulfate reduced per-operative analgesic requirement([5]).

Effects of intraoperative magnesium sulfate administration on postoperative tramadol requirement in liver transplant patients