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Hepatic encephalopathy (HE) is a neurological complication of cirrhosis, impairing survival and quality of life. Its incidence is growing because of the improved prognosis of other complications of cirrhosis, and of the widespread use of TIPS. However, besides hyperammonemia which is often pointed out as a cause of HE, the pathophysiological mechanisms of HE remains poorly understood, which prevents the development of therapeutic strategies. To address this issue, metabolomics was used to identify dysfunction of metabolic pathways in cerebrospinal fluid (CSF) samples of cirrhotic patients suffering from HE.

intensive care medicine experimental

Hepatic encephalopathy in ICU: cerebrospinal fluid metabolomics highlights alteration of multiple metabolic pathways representing new potential therapeutic targets