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Both hypoand hypercapnia can be deleterious to brain injured patients. Due to the variability of CO2 production and elimination and to the unpredictable effects of ventilator settings changes, strict arterial CO2 partial pressure (PaCO2) control is difficult to obtain. Conceivably, using expired (end-tidal) CO2 as the input signal of closed-loop ventilation (Intellivent-ASV) should optimize CO2 control compared to manual ventilator setting changes based on PaCO2 measurements.

intensive care medicine experimental

In neuro critical care, capnia can be optimally controlled using a closed-loop ventilation system based on end-tidal CO2 signal (intellivent-asv®): preliminary results of a prospective interventional study