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Bacterial translocation from the gut has been suggested to induce and maintain the systemic inflammatory response (SIRS) and organ dysfunction. The reticulo-endothelial system in the liver has a pivotal role in clearing the blood from circulating bacteria. To date, the effects of SIRS on hepatic bacterial clearance are not fully understood.

Pre-existing systemic inflammation attenuates bacterial clearance by the liver in porcine abdominal sepsis