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Cluster of Differentiation 64 (CD64) antigen is a membrane glycoprotein expressed on monocytes and macrophages. It is the high affinity neutrophil FcγRI receptor which is weakly expressed by neutrophils at physiological levels, but strongly upregulated within 4-6 hours by the pleiotropic cytokines such as Interferon-γ (IFN-γ) and Granulocyte Colony Stimulating Factor (G-CSF) which are produced in sepsis [1]. CD64 can be used as a diagnostic marker of bacterial infection and sepsis using flow cytometry.

Longitudinal Neutrophil Cd64 Expression As a Biomarker For Acute Infection and Severity of Disease in Critically Ill Patients