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Neurological disturbances and acute kidney injury (AKI) commonly co-exist in critically ill patients. However, it is unclear if AKI directly contributes to neurological disturbances (uremic encephalopathy) or if neurological disturbances and AKI are both reflections of multi-organ failure. Furthermore, it is unclear if renal replacement therapy (RRT) improves outcome, especially if other indications for RRT are absent.

Uremic encephalopathy in critical care: does it exist and does renal replacement therapy improve outcome?