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There is growing evidence that pharmakokinetic parameters of commonly used antibiotics may not be optimal in the critically ill patients. Significant changes of pharmacokinetic parameters, including volume of distribution and clearance, could be expected. Recently, dose increases of antibiotics in the ICU have been advocated to maximise their antibacterial activity, especially when severe infections with high bacterial load and/or multidrug resistance are suspected.

The pharmacokinetics of tigecycline in critically ill adult patients undergoing CVVHD