English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Methods Study developed in three tertiary hospitals in patients with severe sepsis, HDF and treatment with LZ (600mg q12h). 8 each patient blood (prefilter and postfilter) and ultrafiltrate samples were taken. Concentrations of linezolid were determined by HPLC-UV. PK analysis and MCS were performed using Phoenix WinNonlin Version 6.3 (Pharsight) and Oracle Crystal Ball programs to assess the probability of successful treatment (PST) [area under the curve (AUC24)/MIC> 100 for different MICs], the probability of Cmin>2 mg/L and the risk of overexposure (RO) [Cmin> 10 mg /L and/or AUC24> 400 mg * h/L] at doses of 600mg q12 and q8h. Patients were grouped by liver and renal function considering impaired liver function (ILF) the elevation> 2 times transaminase and/or elevated bilirubin and severe renal dysfunction (SRD) the presence of CrCl < 15 ml/min. Group (G) 0: both normal, G1: ILF or SRD, G2: both. Quantitative variables were expressed as mean and standard deviation (SD), qualitative as percentages. a significance level of 0,05.

intensive care medicine experimental

Optimizing the dosing regimen of linezolid in critically ill septic patients undergoing continuous hemodiafiltration using a pharmacokinetic/pharmacodynamic analysis and monte carlo simulation