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The Least Square Fitting (LSF) method is a statistical approach used for evaluating respiratory mechanics [1]. It allows measurement of respiratory mechanics continuously at the bedside, even in presence of flow limitation [23], without the need for constant inspiratory flow rate, end-inspiratory hold and end-expiratory occlusion. These features allow the application of the LSF method to assisted ventilation modes, such as pressure support ventilation (PSV) [3] and neurally-adjusted ventilatory assist (NAVA).

Comparing two different modes of mechanical ventilation by the least square fitting method: nava versus PSV