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Sepsis is an important cause of morbidity and mortality in neonates, especially in premature babies. Rapid and accurate diagnosis of neonatal sepsis is essential to prevent severe and life-threatening complications. However, diagnosis is often difficult as the clinical manifestations of this condition are often subtle and can overlap with those of non-infectious conditions. As a result, clinicians frequently administer empiric antibiotics to symptomatic or “at risk” infants while waiting culture results, which are currently the gold standard to identify bloodstream infection.  Prolonged and inappropriate use of antibiotics is associated with various and well documented complications and adverse events. Therefore, it is mandatory not only to rapidly treat a suspected neonatal sepsis, but also to rule out the infection as soon as possible, in order to stop unnecessary antibiotics.

Rapid diagnosis to rule out bacterial bloodstream infection in neonates