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Intr Several studies have suggested an association between chloride rich fluids and acute kidney injury (AKI) in perioperative and critically ill patients [1]. The mechanism of injury has not been fully described but renal haemodynamic effects and a change in oxidative stress have been hypothesised. Urinary Cystatin C (uCysC) is a sensitive and early marker of renal tubular injury [2]. Levels of uCysC correlate well with adverse clinical outcomes such as AKI and mortality. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been shown to be an excellent predictor of acute renal injury in paediatric and adult cardiac surgery [3] but has not previously been studied in noncardiac surgery.

intensive care medicine experimental

The effect of balanced versus non-balanced fluid replacement on urinary biomarkers in patients undergoing colectomy: a prospective observational pilot study