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Methods Patients within their first 12 hours from admission to the intensive care unit (ICU) during the hemodynamic optimization protocol in which blood transfusion was decided to rise the Sv02 after hemodynamic optimization: central venous pressure (CVP)>8 mmHg, mean arterial pressure (MAP)>65 mmHg, peripheral oxygen saturation (Sp02) >90%. Pre and post transfusion hemoglobin, venous oxygen saturation (Sv02), and V-a PC02 were measured, then divided in two groups: “Responders” (R) if a rise >5%. In Sv02 after transfusion was present and in “Non responders” (NR) with a rise < 5% in Sv02 after transfusion. Receiver Operating Characteristic (ROC) curve analysis was performed to asses the utility of the pre transfusion V-a PC02 as a tool to predict responsiveness of the Sv02 to blood transfusion.

Venoarterial carbon dioxide gradient utility as a criterion for blood transfusion at the intensive care unit