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Oxygen therapy is generally provided via nasal cannula, non-rebreathing masks and masks with reservoir bags. These devices have various limitations.  Despite showing clear benefits in certain conditions, non-invasive positive pressure ventilation (NIPPV) limits mobilization, restricts communication and oral nutrition and is poorly tolerated by some patients due to discomfort.  High-flow nasal cannula oxygen (HFNC) delivers a high flow of heated and humidified oxygen through nasal prongs. It generate positive airway pressure, reduces respiratory dead space, airway resistance, and less frequent interruption of therapy.

intensive care medicine experimental

High flow nasal cannula oxygen (hfnc) versus non-invasive positive pressure ventilation (nippv) in acute hypoxemic respiratory failure. a pilot randomized controlled trial