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Pre-induction of heme oxygenase (HO)-1, which is regarded as an effective method of “organ preconditioning”, exerts beneficial effects during hemorrhagic shock (HS). However, the available HO-1 inducers exhibit disadvantages such as toxicity or complex technical requirements. Therefore, a safe and convenient HO-1 inducer would be promising and could be exploited in the treatment of foreseeable hemorrhaging, such as prior to major surgery. Recently, vitamin C (VitC) has been shown to attenuate organ injuries and inhibit inflammatory responses in hemorrhagic shock [3], but the specific mechanism remains unclear. Studies on the relationship between HO-1 and VitC are limited, and the results are controversial[4, 5].

intensive care medicine experimental

1069. Pharmacological preconditioning with vitamin c attenuates intestinal injury via the induction of heme oxygenase-1 after hemorrhagic shock in rats