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Promotion and improvement of cardiopulmonary resuscitation (CPR) technique contributes to increase of the survivors from unexpected cardiac arrest (CA). However, many patients have some neurological deficits, because of few effective treatment to improve the outcome. Hippocampus damage causes a memory dysfunction which suffers the survivors. Microglia activation caused neuron damage following brain stroke and inhibition of pro-inflammatory soluble epoxide hydrolase (sEH) reduced the infarction size in partial ischemia mice model.

intensive care medicine experimental

0601. An inhibitor of pro-inflammatory enzyme soluble epoxide hydrolase improves hippocampus dependent memory function after cardiac arrest and cardio-pulmonary resuscitation in mice