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Cardiac arrhythmias are a major cause of morbidity and mortality. Their overall incidence is reported to vary between 14 and 19 percent in adult patients admitted to intensive care units [1]. Even in patients without prior heart pathologies, an electrical instability could be detected during repolarisation shortly before cardiac arrest with a high resolution ECG, not recordable with a conventional ECG [1]. Furthermore the effects of disease pattern and intensive care measures e.g. sepsis and elevated intracranial pressure and the administration of pressure support on heart rate and variability is poorly described and understood. In contrast even minor circadian beat to beat variations might precede the occurrence of potentially life threatening arrhythmias. Thus circadian haemodynamic profiles might thus be a marker of potentially life threatening arrhythmias and an early predictor of prognosis. It seems therefore of importance to recognize even small changes of the circadian cardiac rhythm as early as possible.

0600. Altered electrical activity of the heart in pigs during apnoea