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In addition to lipid-lowering effects HMG-CoA reductase inhibitors like pravastatin also modulate the microcirculation [1]. The exact mechanisms are yet unknown and results are heterogeneous, with both positive and negative effects on endothelial microvascular function [2, 3] being reported.

intensive care medicine experimental

0589. Pravastatin exerts opposite effects on splanchnic microcirculatory oxygenation during sham or septic conditions in an animal model of polymicrobial sepsis