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Bacterial Colonization (0.22 vs 2.27 and 2.31 log cfu/gr, p< 0.05) and VAP (0 vs 67 and 86 %, p< 0.05) were drastically reduced in TL position as compared to SR and SR-inv respectively. MAP was lower in SR and SRinv compared to TL position (80 and 73 vs 90 mmHg, p< 0.05). At the brain level, pigs in TL position presented high score of petequial hemorrhage (2.6 vs 1 and 1.5, p< 0.05), and higher levels of immunopositive cells to caspase (6.3 vs 2.5 and 1.7, p< 0.05) and TUNEL (5.17 vs 1 and 2.72, p< 0.05) in the dentate gyrus in the hippocampus, both indicators of apoptosis, in comparison with groups SR and SR-inv respectively. Conclusions In this pig model of MV, TL position prevents pulmonary colonization and VAP development, but enhances cerebral hemorrhage, and increased apoptosis in the hippocampus. These alterations in the brain could be related with the increase in MAP observed in TL position. More studies to evaluate risks and benefits of TL position are needed.

0468. Cerebral effects of lateral trendelenburg vs semirecumbent position in an experimental model of ventilator-associated pneumonia