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The aim of the present study was to determine the sensitivity pattern of clinical isolates of otitis media. During the last few decades, the occurrence of otitis media seems to have been rising probably because of prevalence of multidrug-resistant  Pseudomonas aeruginosa  and β-lactamase producing  Staphylococcus aureus  in the pathogenesis of otitis media.  Pseudomonas aeruginosa  and  Staphylococcus aureus  were the most common causative microorganisms of ear infection. Keeping in view the importance of these pathogens, the present study had been designed to determine the sensitivity pattern of clinical isolates of otitis media. These isolates were collected from different hospitals and pathological laboratories of Karachi and their sensitivity against cefepime and amoxicillin were determined by using disk diffusion method. The results have shown that  Pseudomonas aeruginosa  was the most common causative microorganism of ear infection. Cefepime, a fourth generation cephalosporin appeared to be an effective antibiotic against  Pseudomonas aeruginosa  and  Staphylococcus aureus .

Antimicrobial susceptibility pattern of clinical isolates from cases of ear infection using amoxicillin and cefepime