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Background  Transcranial Doppler (TCD) CO 2 -reactivity and oxygen-15 positron emission tomography (PET) have both been used to measure the cerebral haemodynamic state in patients who may have a compromised blood flow. Our purpose was to investigate whether PET and TCD identify the same patients with an impaired flow state of the brain in patients with internal carotid artery (ICA) occlusion.    Methods  Patients with recent transient ischaemic attack or minor ischaemic stroke associated with ICA occlusion underwent TCD with measurement of CO 2 -reactivity and oxygen-15 PET within a median time interval of 6 days.    Results  We included 24 patients (mean age 64 ± 10 years). Seventeen (71%) patients had impaired CO 2 -reactivity (≤20%), of whom six had absent reactivity (0%) or steal (<0%) in the hemisphere ipsilateral to the ICA occlusion. PET of the perfusion state of the hemisphere ipsilateral to the ICA occlusion demonstrated stage 1 haemodynamic compromise (decreased cerebral blood flow (CBF) or increased cerebral blood volume (CBV) without increased oxygen extraction fraction (OEF)) in 13 patients and stage 2 (increased OEF) in 2 patients. In 12 patients (50%), there was agreement between TCD and PET, indicating haemodynamic compromise in 10 and a normal flow state of the brain in 2 patients. There was no significant correlation between CO 2 -reactivity and CBF ipsilateral/contralateral hemispheric ratio ( r  = 0.168,  p  value = 0.432), OEF ratio ( r  = −0.242,  p  value = 0.255), or CBV/CBF ratio ( r  = −0.368,  p  value = 0.077).    Conclusions  In patients with symptomatic ICA occlusion, identification of an impaired flow state of the brain by PET and TCD CO 2 -reactivity shows concordance in only half of the patients.

ejnmmi research

Comparison of oxygen-15 PET and transcranial Doppler CO2-reactivity measurements in identifying haemodynamic compromise in patients with symptomatic occlusion of the internal carotid artery