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A modified 6-phosphofructo-1-kinase was expressed in a citrate producing  Aspergillus niger  strain in combination with  cis -aconitate decarboxylase from  Aspergillus terreus  to study the effect on the production of itaconic acid. The modified  pfkA  gene was also expressed in combination with the itaconic acid biosynthetic cluster from  A. terreus , which consists of  cis- aconitate decarboxylase  cadA , a putative mitochondrial transporter  mttA  and a putative plasmamembrane transporter  mfsA . The combined expression of  pfkA  and  cadA  resulted in increased citrate levels, but did not show increased itaconic acid levels. The combined expression of  pfkA  with the itaconic acid biosynthetic cluster resulted in significantly increased itaconic acid production at earlier time points. Also the itaconic acid productivity increased significantly. The maximum itaconic acid productivity that was reached under these conditions was 0.15 g/L/h, which is only a factor 17 lower than the 2.5 g/L/h that according to the US Department of Energy should be achieved to have an economically feasible production process.

Overexpression of a modified 6-phosphofructo-1-kinase results in an increased itaconic acid productivity in Aspergillus niger