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Background  Monitoring hepatic blood flow and function might be crucial in treating critically ill patients. Intra-abdominal hypertension is associated with decreased abdominal blood flow, organ dysfunction, and increased mortality. The plasma disappearance rate (PDR) of indocyanine green (ICG) is considered to be a compound marker for hepatosplanchnic perfusion and hepatocellular membrane transport and correlates well with survival in critically ill patients. However, correlation between PDR ICG  and intra-abdominal pressure (IAP) remains poorly understood. The aim of this retrospective study was to investigate the correlation between PDR ICG  and classic liver laboratory parameters, IAP and abdominal perfusion pressure (APP). The secondary goal was to evaluate IAP, APP, and PDR ICG  as prognostic factors for mortality.    Methods  A total of 182 paired IAP and PDR ICG  measurements were performed in 40 critically ill patients. The mean values per patient were used for comparison. The IAP was measured using either a balloon-tipped stomach catheter connected to an IAP monitor (Spiegelberg, Hamburg, Germany, or CiMON, Pulsion Medical Systems, Munich, Germany) or a bladder FoleyManometer (Holtech Medical, Charlottenlund, Denmark). PDR ICG  was measured at the bedside using the LiMON device (Pulsion Medical Systems, Munich, Germany). Primary endpoint was hospital mortality.    Results  There was no significant correlation between PDR ICG  and classic liver laboratory parameters, but PDR ICG  did correlate significantly with APP ( R  = 0.62) and was inversely correlated with IAP ( R  = -0.52). Changes in PDR ICG  were associated with significant concomitant changes in APP ( R  = 0.73) and opposite changes in IAP ( R  = 0.61). The IAP was significantly higher (14.6 ± 4.6 vs. 11.1 ± 5.3 mmHg,  p  = 0.03), and PDR ICG  (10 ± 8.3 vs. 15.9 ± 5.2%,  p  = 0.02) and APP (43.6 ± 9 vs. 57.9 ± 12.2 mmHg,  p   < 0.0001) were significantly lower in non-survivors.    Conclusions  PDR ICG  is positively correlated to APP and inversely correlated to IAP. Changes in APP are associated with significant concomitant changes in PDR ICG , while changes in IAP are associated with opposite changes in PDR ICG , suggesting that an increase in IAP may compromise hepatosplanchnic perfusion. Both PDR ICG  and IAP are correlated with outcome. Measurement of PDR ICG  may be a useful additional clinical tool to assess the negative effects of increased IAP on liver perfusion and function.

annals of intensive care

Relationship between intra-abdominal pressure and indocyanine green plasma disappearance rate: hepatic perfusion may be impaired in critically ill patients with intra-abdominal hypertension