English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background  Community-acquired necrotizing pneumonia caused by Panton-Valentine leukocidin (PVL)-secreting  Staphylococcus aureus  is a highly lethal infection that mainly affects healthy children and young adults. Both methicillin-sensitive  S. aureus  (MSSA) and methicillin-resistant  S. aureus  (MRSA) may carry the PVL-phage, but the majority of publications relate to community-associated methicillin-resistant  S. aureus  (CA-MRSA) or mixed patient groups. This study focuses on necrotizing pneumonia due to methicillin-sensitive  S. aureus  strains, with the purpose to determine factors associated with outcome.    Methods  We report a patient with PVL secreting MSSA necrotizing pneumonia and performed a systematic review of similar case in the literature. We analyzed factors associated with outcome.    Results  A total of 32 patient descriptions were retained for analysis. Septic shock ( p  = 0.007), influenza-like prodrome ( p  = 0.02), and the absence of a previous skin and soft-tissue infection ( p  = 0.024) were associated with fatal outcome. In multivariate analysis, influenza-like prodrome (odds ratio (OR), 7.44; 95% confidence interval (CI), 1.24-44.76;  p  = 0.028) and absence of previous skin and soft-tissue infection (OR, 0.09; 95% CI, 0.01-0.86;  p  = 0.036) remained significant predictors of death.    Conclusions  Influenza-like prodrome may be predictive of adverse outcome in PVL-secreting MSSA necrotizing pneumonia. In contrast, previous skin and soft-tissue infection may be associated with improved prognosis.

annals of intensive care

Community-acquired necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin: a review of case reports