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We applied our new method, maturity-dependent fractionation of bone marrow-derived neutrophil progenitors, to a study of gene expression profiles during granulopoiesis in myelodysplastic syndromes. CD34 +  cells with low density [F1], CD11b - /CD16 -  [F2], CD11b + /CD16 -  [F3] and CD11b + /CD16 low  [F4] with intermediate density, CD11b + /CD16 int  [F5] and CD11b + /CD16 high  [F6] with high density were isolated from six patients. Although AML1 and C/EBP-ϵ mRNA peaked at F1 and F4, respectively, in healthy individuals, C/EBP-ϵ was maximized at F2/F3 in all patients, two of whom showed simultaneous peaks of AML1 at F2. Thus, this fractionation is useful to detect mistimed induction of granulopoiesis-regulating genes in myelodysplastic syndromes.

A new method for maturity-dependent fractionation of neutrophil progenitors applicable for the study of myelodysplastic syndromes