English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Sepsis is a medical condition caused by severe infection with systemic inflammation, substantial morbidity and poor survival prognosis. Major clinical features of sepsis include abnormally low blood pressure, decreased peripheral vascular resistance, micro-vascular leak, and decreased cardiac output. Together this leads to inadequate perfusion of vital organs which can result in their necrosis, and often patient death. Multiple oxidant-generating systems contribute to increased level of oxidants, such as hydrogen peroxide, peroxynitrite and nitrosothiols during sepsis. Previously we demonstrated that oxidants can activate PKGIa to lower blood pressure. In a current study we hypothesised that oxidative activation of PKG underlies sepsis-induced hypotension and consequential organ injury.

Protein kinase G oxidation contribute to hypotension and organ injury during sepsis