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Background Soluble guanylyl cyclase (sGC) plays an important role in cardiovascular homeostasis and its activity is crucial for maintaining vascular plasticity. Diminished sGC expression and activity is associated with the development of endothelial dysfunction and increase in vascular stiffness. We have previously demonstrated that alternative splicing of sGC transcripts produces sGC splice forms with altered enzymatic and regulatory properties. However, splicing of sGC genes in human aortic tissue was never investigated.

Alternative splicing of α1 and β1 sGC genes is altered in aortic disease