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Background The obesity-associated insulin resistance has been shown to play an important role in the pathophysiology of overactive bladder in mice [1,2]. Therefore, we evaluated the beneficial effects of long-term administration of the sGC activator BAY 60-2270 in bladders from lean and obese mice. Methods Mice were fed for 12 weeks with either a standard chow diet (carbohydrate: 70%; protein: 20%; fat: 10%) or a high fat diet that induces obesity (carbohydrate: 29%; protein: 16%; fat: 55%). Lean and obese mice were orally treated with BAY 60-2770 (1 mg/kg/day, given as daily gavage

The soluble guanylyl cyclase activator BAY 60-2770 ameliorates detrusor dysfunction in obese mice