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Background Peptide YY (PYY) and neuropeptide Y (NPY), two members of the pancreatic polypeptide-fold family of biologically active peptides, play important roles in the regulation of food intake, energy homeostasis and emotional-affective processes. While NPY also participates in nociceptive processing and cognition, the implication of PYY in pain, learning and memory has been little studied. Therefore, male wild-type, PYY knockout (PYY(−/−)), and NPY plus PYY double knockout (NPY(−/−);PYY(−/−)) mice were studied for their sensitivity to noxious heat in the plantar test and for their spatial learning and memory performance in the Barnes maze.

Peptide YY and neuropeptide Y in regulation of pain and spatial learning and memory