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Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Graz, Austria, and Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA Correspondence Dr Bernd Mayer or Dr Astrid Schrammel, Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Universitätsplatz 2, A-8010 Graz, Austria. E-mail: mayer@uni-graz.at (B.M.); astrid.schrammel-gorren@uni-graz.at (A.S.)

Tolerance to nitroglycerin through proteasomal degradation of aldehyde dehydrogenase-2 in a genetic mouse model of ascorbate deficiency