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Background Perivascular adipose tissue (PVAT) has been recognized as an important factor in vascular biology due to its ability to produce a variety of vasoactive substances. In addition, it is regarded as an important source of proinflammatory mediators and reactive oxygen species (ROS). Experiments from our laboratory demonstrated that mice lacking adipose triglyceride lipase (ATGL), a crucial enzyme of triglyceride catabolism, suffer from severe microand macrovascular endothelial dysfunction. Since blood vessels of ATGL knockout mice (ATGL(−/−) mice) are surrounded by large amounts of PVAT, we investigated its potential contribution to the observed endothelial dysfunction.

Role of perivascular adipose tissue in endothelial dysfunction of adipose triglyceride lipase-deficient mice