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The Kona Medical Surround Sound™ System is a fully non-invasive system for renal denervation which employs ultrasound based imaging for targeting and tracking as well as a phased array therapeutic ultrasound transducer. To date, 69 patients have been treated under three different protocols (WAVE I, WAVE II, and WAVE III).  Follow up ranges from 3 months to over 2 years. A subset of 18 patients (WAVE II) was chosen for detailed analysis using numerical simulation. Aims: To evaluate safety, feasibility, and a specific dose strategy using a computational model in a Virtual Acoustic Patient (VAP) model and validate these simulations with human data.

journal of therapeutic ultrasound

Renal denervation using externally delivered focused ultrasound: summary of clinical experience to date and validation of supporting computational simulations