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Background Mild hyperthermia (41.5-44°C) has been shown to enhance the effect of radiotherapy and chemotherapy. However, currently available heating methods are often inefficient in inducing conformal hyperthermia for deep seated targets. Here, the software of Philips Sonalleve V2 MR-HIFU system was modified to enable performing a long duration large volume hyperthermia sonication in in-vivo porcine thigh muscle.

Large volume 60 minute hyperthermia sonication with hilips Sonalleve V2 MR-HIFU System – animal in-vivo experiment