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Methods Oxylipins were extracted from 197 cord blood plasma samples from the ENVIRONAGE (ENVIRonmental influence ON AGEing in early life) birth cohort in Belgium. Thirty-seven specific oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15LOX) and cytochrome P450 (CYP) metabolic pathways were quantified by ultra-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS). Principal component analysis and multiple regression models were applied to associate oxylipin pathways as well as individual metabolites with in utero PM2.5 exposure, while adjusting for newborns gender, gestational duration, maternal age, maternal smoking status, maternal BMI, and cord blood total cholesterol and HDL levels.

Altered neonatal cord blood oxylipidome in association with exposure to particulate matter in the early life environment