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Materials and methods CWR22Rv1 cells (a castrate-resistant human PCa cell line) were treated with a polyherbal mixture of botanicals (PHBs) consisting of 10 herbal extracts [1] and we investigated whether inhibition of cell proliferation was linked to the activity of 5’adenosine monophosphate (AMP)activated protein kinase (AMPK), a potential tumor suppressor protein that functions as a central energy sensor within the cell. In addition, we investigated whether this inhibition was also the result of synergy among the bioactives as determined by the Chou-Talalay method [2].

The interaction of botanicals and AMPK signaling in the inhibition of castrate-resistant prostate cancer