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Background  We aimed to evaluate the frequency of various types of B and T cells expressing CD21, CD32, and CD35 in multiple sclerosis (MS) clinical courses.    Methods  Peripheral blood mononuclear cell from 30 MS patients (17 relapsing remitting [RRMS], six secondary progressive [SPMS], and seven primary progressive MS [PPMS]) and 18 healthy subjects were analyzed. All patients were in acute attack. Healthy controls were matched for age and gender ratio. The frequencies of various subsets of B and T cells were determined using flow cytometry.    Results  The frequency of CD4 + T cells was lower in MS patients compared to control subjects (41.14 ± 9.45% vs. 46.88 ± 6.98%, respectively,  P  < 0.05). The CD32 +  fraction of CD4 + T cells and the CD21 +  fraction of CD8 + T cells were higher in MS patients (2.85 ± 3.72% vs. 1.06 ± 0.62% for CD32 + CD4 + T cells, 2.71 ± 1.86% vs. 1.16 ± 0.99% for CD21 + CD8 + T cells in MS patients and control subjects, respectively,  P  < 0.05). After dividing subjects by type of MS course, higher values of these two T cell subsets were found in SPMS patients compared to control subjects ( P  < 0.05). Further, RRMS patients had lower levels of CD32 + CD4 + T cells than SPMS patients and also they had lower levels of CD32 + CD8 + T cells than PPMS patients ( P  < 0.05). However, neither the expression of CD35 on T cells nor the various B cell subsets were statistically different between the compared groups.    Conclusions  Our findings demonstrate that T cell subsets expressing CD21 and CD32 may differ with respect to the presence or clinical forms of MS disease. By contrast, CD35 + T cells and different subsets of B cells are not altered in various MS clinical courses.

Cytometric profiling in various clinical forms of multiple sclerosis with respect to CD21+, CD32+, and CD35+ B and T cells