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Carbapenem resistance occurs via two mechanisms: acquisition of resistance genes (NDM-1, KPC, OXA) or combination of extended spectrum beta-lactamase production and alteration of the expression of porins (NCP Enterobacteriaceae).

antimicrobial resistance and infection control

Comparative risk factors for nosocomial New Delhi metallo-beta-lactamase (NDM-1) producing Enterobacteriaceae and non-carbapenemase producing (NCP) Enterobacteriaceae