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Vancomycin overuse exerts a selective pressure for VRE and VISA and has been associated with poorer outcomes than beta-lactams when treating MSSA. Rapid determination of methicillin susceptibility should be particularly helpful to spare vancomycin in a setting where MRSA prevalence is low.

antimicrobial resistance and infection control

Rapid molecular diagnosis using femA mecA real-time PCR for staphylococcal bacteraemia improves early appropriate antibiotic prescribing: a randomised clinical trial