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Methods The 2/3 generation cephalosprines (GCPs) use from 2006.1 to 2012.12 was converted to DDDs per 1,000 patientdays in a tertiary teaching infectious disease hospital in Tianjin, China. Multi-strategy, including contextually appropriate antibiotic use guidelines, active audit, as well as performance feedback/education in-field, were conducted by antimicrobial stewardship in the hospital since 2006. E. coli and K. pneumoniae isolated from all identified and suspected infections were selected at the same time. For ESBLs status, agar diffusion test with clavulanic acid plus or minus cefotaxime and ceftazidime was used. Linear correlation was carried out to analyze the relationship between 2/3 GCPs use and major Enterobacteriaceae producing ESBLs.

antimicrobial resistance and infection control

P095: The 2nd/3rd generation of cephalosprines use in antimicrobial stewardship program and contemporary carriage of E. coli and K. pneumoniae with esbls from identified or suspected infection hospitalized patients