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Among 145 patients with gram-negative COB, 83 (57.2%) had HCAB and 62 (42.8%) had CAB. The frequency of malignant tumors, renal insufficiency and dementia was higher in patients with HCAB than with CAB. In both groups Escherichia coli was the mostcommon causative agent but the prevalence of Klebsiella pneumoniae in HCAB was significantly higher than CAB (19.3% vs. 4.8%). Patients with HCAB had higher Charlson score and higher Pitt bacteremia score, less frequent administration of appropriate empirical antibiotic treatment and higher probability of death than patients with CAB. The antimicrobial resistance in HCAB aι CAB patients respectively, was found 27/83 (32.5%) vs. 4/62 (6.5%) (P<.001) to third-generation cephalosporins (3GC), 22/83 (26.5%) vs. 7/62 (11.3%) (P=.021) to aminoglycosides, 29/83 (34.9%) vs. 9/62 (14.5%) (P=.005) to quinolones. Bacteria that produced ESBL were 16/76 (21.1%) vs. 2/59 (3.4%) (P=.003), and carbapenem-resistant were 10/83 (12.0%) vs. 2/62 (3.2%) (P=.056) in HCAB aι CAB patients respectively Conclusion There are significant differences in the severity of underly- ing diseases, causative pathogens, antibiotic resistance, outcome and treatment between the two groups. In our region 3GC, aminoglycosides or fluoroquinolones are pro- posed as appropriate empirical treatment for patients with CAB, whereas in patients with HCAB carbapenems should be the initial therapy. Disclosure of interest None declared.

P009: Epidemiology, microbiology and outcome of community-οnset gram-negative bacteremias in a Greek University Hospital