English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

India has very high rates of ESBL producing gram negative organisms and co-production of AmpC & OXA makes majority of antibiotics resistant, leaving carbapenems only reliable options. In recent times, E.coli and Klebsiella pneumoniae have also started showing resistance to carbapenems. Cefepime, a 4th generation cephalosporin, is stable against AmpC & OXA, but it lacks activity against ESBL producing organisms. Clavulanate is a highly effective inhibitor of extended-spectrum beta-lactamases (ESBLs) in detection tests. A novel combination of Cefepime-tazobactam is expected to increase susceptibility of Enterobacteriaceae otherwise resistant to cefepime if used alone.The combination of Cefepime-tazobactam may effectively cover all three major resistance mechanisms (AmpC & OXA by cefepime, ESBLs by tazobactam).

P081: Cefepime-tazobactam: a new antibiotic against ESBL producing enterobacteriaceae in cancer patients